by Cpt1Eye » Fri Feb 10, 2012 1:14 pm
They require some ability to clear your mind and meditate, and that's not an easy thing to do, plus you'll need to practice them beyond that. However, once you're to the point of getting the full effect of a dose, there's little that differentiates them from the real thing, with few exceptions.
Well, across the board you won't have negative side effects, like hangovers, I guess that's always a difference.